Dosage regimen loading dose

The maintenance dose may be defined as the size of the dose required to maintain the therapeutic range according to the dosage regimen. The maintenance dose needed to replace the amount lost over the dosing interval is the difference between the loading dose and the amount remaining at the end of the interval. It is calculated as,... 

Leflunomide is taken orally. In most regimens it is begun with a loading dose of 100 mg/day over 3 days followed by a maintenance dosage of 10-20 mg/day. Leflunomide 100 mg/week had similar effectiveness and less toxicity in open trials compared with daily dosing (21,93). 

Most drug or their metabolites that are normally excreted unchanged by the kidney will require dosage modification in advanced renal failure. The loading dose of a drug will stay the same unless the is significantly altered. The maintenance regimen may be... 

Drug dosage regimens The efficacy and tolerability of an oral oxcarbazepine loading dose of 30 mg/kg was assessed in 40 adolescent and adult patients. The most common adverse effect was dizziness, followed by nausea/ vomiting, nystagmus, ataxia, and diplopia. Most of these adverse effects occurred shortly after administration, and did not correlate with plasma levels of the medication [113 ]. 

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