Dosage future directions

Future directions for research on hypericum may continue the work done in clinical efficacy. More specifically, studies may be of interest that examine its effects in treatment of more severe depression and different subtypes of depression. The comparative efficacy of different hypericum preparations could be further investigated, and optimum dosages need to be established (Linde et al. 1996). Further work is needed to compare hypericum s efficacy and side effects with those of the SSRIs or atypical antidepressants, because published studies to date have only compared it with tricyclics. 

With a good pharmacokinetic model and parameter values determined in similar patients, it becomes possible to calculate successful dosage regimens for future patients, either directly or by using a Bayesian analysis with limited patient data. 

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