DOPC with Phosphatidic Acid under Sink Conditions

3 DOPC with Phosphatidic Acid under Sink Conditions 

4 DOPC with Phosphatidylglycerol under Sink Conditions 

The PG models 9.1 and 10.1 show similar trends as indicated by PA, but the effects are somewhat muted. The increase in PG from 0.6% to 1.1% causes the permeabilities of weak bases to decrease and membrane retentions to increase, with many bases showing R 60%. Many molecules were not detected in the acceptor compartments by UV spectrophotometry after 4 h permeation times (Table 7.7). These properties of the PG system make it less attractive for high-throughput applications than the other two-component models. 

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