Dopaminergic neurotransmission function

Since cocaine potentiates dopaminergic neurotransmission by binding to DA transporter and blocking reuptake, persisting increases in DA transporter function after cocaine levels have fallen... 

All the pharmacological and behavioural effects elicited by dopamine agonists and antagonists in the brain can only be explained if such an interaction occurs at the level of the dopamine receptor (D2 receptor site) the site still remains in search of a function. Bovine parathyroid cells were reported to possess dopamine sites which should be involved in the control of parathormone secretion. However, the very poor pharmacological characterization and the lack of in vivo evidence do not allow to assess the dopaminergic nature of this hormone secretion. Dopamine-sensitive adenylate cyclase is thus not a receptor directly implicated in the dopaminergic neurotransmission it is an enzyme which could have an important role in the control of long term metabolic effects such as the synthesis of neuronal constituents. 

From these considerations, one may conclude that the site is not directly implicated in dopaminergic neurotransmission this does not exclude a possible functional role for the cyclase but hitherto it remains unknown. A possible hypothesis is that the cyclase may control long term metabolic effects such as the synthesis of neuronal constituents. 

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