Foods Dopamine agonists

G02C B Prolactin inhibitors Bromocryptine is a semisynthetic ergot alkaloid, 2-bromoergo-cryptine and acts as an dopamine-agonist (i.e. has the same effect as dopamine) with a long duration and is an inhibitor of prolactin and growth hormone. For the indication inhibition and cessation of lactation one starts with a low dose 2.5 mg taken with food for two weeks. 

Piribedil ( ), a dopamine agonist, suppresses food intake in rats and this effect is not antagonized by a-methyl-p-tyrosine, metergoline, propranolol, phentolamine or domperidone but is blocked by pimozide. Motor activity is increased at 2 to 3 times the doses needed for food intake suppression. 

Dopamine agonists stimulate the dopamine receptors and reduce the symptoms of Parkinson s disease. MAO-B inhibitors inhibit the catabolic enzymes that break down dopamine thereby extending the effects of dopamine. However they can cause a h5 ertensive crisis if taken with certain foods (see Table 15-1). 

Food did not alter the pharmacokinetics of bromocriptine, cabergoline or lisuride. These dopamine agonists are usually taken with food to try and improve their tolerability. 

Bromocriptine (Parl el) [Antiparkinsonian Agent/Dopamine Receptor Agonist] Uses Parkin on Dz, hyperprolactinemia, acromegaly, pituitary tumors Action Direct-acting on the striatal dopamine receptors X prolactin secretion Dose Initial, 1.25 mg PO bid titrate to effect, w/ food Caution [B, ] Contra Severe ischemic heart Dz or PVD Disp Tabs, caps SE X BP, Raynaud phenomenon (vasospastic disorder resulting in discoloration of the fmgers/toes), dizziness, N, hallucinations Interactions T Effects W/ erythromycin, fluvoxamine, nefazodone, sympathomimetics, antihypertensives X effects W/ phenothiazines, antipsychotics EMS Monitor BP may cause intolerance to EtOH OD May cause NA, severe hypotension give IV fluids symptomatic and supportive... 

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