Donors blood pressure control

Some published papers have described a strategy to increase the cell uptake of Ru -NO and improve blood pressure control (48,53,54) Essentially, liposome, solid nanoparticles, and gold nanoparticle have enabled encapsulation/anchoring of the NO-donor ruthenium complexes. Slow decomposition of the nanoparticle, followed by an intracellular chemical process or by light irradiation of the encapsulated compound, produces... 

Physiologically, in both normal and hypertensive individuals, blood pressure is maintained by moment-to-moment regulation of cardiac output and peripheral vascular resistance, exerted at three anatomic sites (Figure 11-1) arterioles, postcapillary venules (capacitance vessels), and heart. A fourth anatomic control site, the kidney, contributes to maintenance of blood pressure by regulating the volume of intravascular fluid. Baroreflexes, mediated by autonomic nerves, act in combination with humoral mechanisms, including the renin-angiotensin-aldosterone system, to coordinate function at these four control sites and to maintain normal blood pressure. Finally, local release of hormones from vascular endothelium may also be involved in the regulation of vascular resistance. For example, nitric oxide (see Chapter 19 Nitric Oxide, Donors, Inhibitors) dilates and endothelin-1 (see Chapter 17 Vasoactive Peptides) constricts blood vessels. 

Marcondes FG, Ferro AA, Sousa-Torsoni A, et al. In vivo effects of the controlled NO donor/scavenger ruthenium cyclam complexes on blood pressure. Life Sci 2002 70 2735-52. 

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