Donors biochemical pharmacology

Nitric Oxide Donors Biochemical Pharmacology and Therapeutics... 

I. Biochemical Pharmacology of NO Donors How and Where Do They Generate NO ... 

As a class, the compounds derived from purine and pyrimidine bases are of considerable biochemical interest, particularly if they are the constituents of the nucleic adds. With their many hydrogen-bonding donor and acceptor functions, these molecules can interact specifically with the enzymes involved in the metabolism of the nucleic acids and with regulatory proteins. Purines, pyrimidines, and their derivatives have been used most successfully in the investigations of biological processes and have found application in pharmacology [520, 521]. The same is true for the barbiturates, where the main emphasis is in pharmaceutical industry. 

All NO donors apparently rely on the generation of NO for their pharmacological activities. However, beyond this general similarity lie several important questions Do all NO donors release NO in vivo by the same mechanism If not, how do they differ biochemically Do the biochemical... 

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