Sertraline Donepezil

Sertraline augmentation in the treatment of the behavioral manifestations of Alzheimer s disease in outpatients treated with donepezil has been evaluated (40). There were no significant differences on primary endpoints. Diarrhea was more common with donepezil + sertraline group compared with donepezil + placebo. 

Winhusen T.M., Somoza E.C., Harrer J.M. et al. A placebo-controlled screening trial of tiagabine, sertraline and donepezil as cocaine dependence treatments. Addiction. 100(Suppl. 1) 68, 2005. 

Fluvoxamine markedly increases the levels of tacrine, and increases its cholinei ic adverse effects, whereas fluoxetine, paroxetine, and sertraline are not expected to interact. Paroxetine and fluoxetine may increase donepezil and galantamine levels. Sertraline does not appear to have a pharmacokinetic interaction with donepezil, and concurrent use seems generally well tolerated however, one report describes hepatotoxicity, possibly as a result of their concurrent use. Rivastigmine and fluoxetine appear not to interact. 

Nagy CF, Kumar D, Perdomo CA, Wason S, Cullen El, Pratt RD. Concurrent administrati( i of donepezil HCl and sertraline HCl in healthy volunteers assessment of pharmacokinetic changes and safety following single and multiple oral doses. BrJ Clin Pharmacol (2004) 58,... 

Finkel SI, Mintzer JE, Dysken M, Krishnan KR, Burt T, McRae T. A randomized, placebo-controlled study of the efficacy and safety of sertraline in the treatment of the behavioral manifestations of Alzheimer s disease in ou atients treated with donepezil. IntJGeriatrP chi-... 

Verrico M M, Nace DA, Towers AL. Fulminant chemical hepatitis possibly associated with donepezil and sertraline therapy. JAm GeriatrSoc (2000) 48, 1659- 3. 

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