Ginkgo biloba Donepezil

Yasui-Furukori N, Furukori H, Kaneda A, Kaneko S, Tateishi T. The effects of Ginkgo biloba extracts on the pharmacokinetics and pharmacodynamics of donepezil. J Clin Pharmacol 2004 44 538-542. 

In a pharmacokinetic study 14 elderly patients with Alzheimer s disease were given donepezil 5 mg daily for at least 20 weeks, after whieh Ginkgo biloba extract 90 mg daily was also given for a further 30 days. Coneur-rent use did not affect the pharmacokinetics or cholinesterase aetivity of donepezil, and cognitive function appeared to be unehanged. Therefore, over the course of 30 days, coneurrent use appears neither benefieial nor detrimental. 

Yancheva S, Ihl R, Nikolova G, Panayotov P, Schlaefke S, Hoerr R (2009) Ginkgo biloba extract EGb 761(R), donepezil or both combined in the treatment of Alzheimer s disease with neuropsychiatric features a randomised, double-blind, exploratory trial. Aging Ment Health 13(2) 183-190. doi 10.1080/13607860902749057... 

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