Dolichol-phosphatate-mannose synthase

R Mazhari-Tabrizi, V Eckert, M Blank, R Muller, D Mumberg, M Funk, RT Schwarz. Cloning and functional expression of glycosyltransferases from parasitic protozoans by heterologous complementation in yeast the dolichol phosphate mannose synthase from Trypanosoma brucei. Biochem J 316 853-858, 1996. 

Orlean, P., Albright, C., and Robbins, P. W. (1988). Cloning and sequencing of the yeast gene for dolichol phosphate mannose synthase, an essential protein./. Biol. Chem. 263,17499-17507. 

Fig. 20.1. Abbreviated scheme of the synthesis of a diantennary N-glycan. Fucose modification has been omitted. 20.1, Phosphomannomutase 2 (PMM2) 20.2, phosphoman-nose isomerase (PMI) 20.3, glucosyltransferase I (GT I) 20.4, mannosyltransferase VI (MT VI) 20.5, dolichol phosphate-mannose synthase-1 (DPM synthase-1) 20.5, N-acet-ylglucosaminyltransferase II (GnT II) 20.7, glucosidase I (G I) GDP, guanosine diphosphate Marly mannose GlcNACy N-acetylglucosamine Do/, dolichol P, phosphate G/c, glucose Gal galactose SiUy sialic acid. Dotted arrow indicates multiple steps...

Table 20 5 Dolichol phosphate-mannose synthase-1 deficiency (CDG-Ie)...

Kim S, Westphal V, Srikrishna G, et al. Dolichol phosphate mannose synthase (DPMI) mutations define congenital disorder of glycosylation le (CDG-Ie). / Clin Invest 2000 105 191-198. 

Imbach T, Schenk B, Schollen E, et al. Deficiency of dolichol-phosphate-mannose synthase-1 causes congenital disorder of glycosylation type le. / Clin Invest 2000 105 233-239. 

P.A. Colussi, C.H. Taron, J.C. Mack, and P. Orlean, Human and Saccharomyces cerevisiae dolichol phosphate mannose synthases represent two classes of the enzyme, but both function in Schizosaccharomyces pomhe, Proc. Natl Acad. Sci. USA 1997, 94, 7873-7878. 

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