Terfenadine Docetaxel

Clinically important, potentially hazardous interactions with alprazolam, astemizole, carbamazepine, cisapride, clarithromycin, dexamethasone, diltiazem, docetaxel, ifosfamide, imatinib, irinotecan, itraconazole, ketoconazole, methylprednisolone, midazolam, nefazodone, oral contraceptives, paroxetine, phenytoin, pimozide, rifampin, ritonavir, terfenadine, tolbutamide, trabectedin, troleandomycin, vinblastine, vincristine, warfarin... 

CYP3A4 Amitryptiline, Imipramin, Cyclosporine, Docetaxel, Epipodophyllotoxin, Erythromycin, Losartan, Diazepam, Carbamazepine, Nefadozone, Nifedipine, Omeprazole, Terfenadine, Chlorpyrifos (Insecticide), Testosterone, Estradiol, Progesterone, and synthetic sexual steroids... 

In vitro studies have found that quinupristin/dalfopristin inhibits the CYP3A4-mediated metabolism of docetaxel, tamoxifen and terfenadine and is predicted to inhibit the metabolism of other drugs by this enzyme system. 

In vitro studies found quinupristin/dalfopristin inhibited the cytochrome P450 isoenzyme CYP3A4-mediated metabolism of docetaxel, tamoxifen, and terfenadine. Quinupristin/dalfopristin is predicted to raise the levels of other drugs ineluding antiarrhythmics (disopyramide, lidocaine, quinidine), antiretrovirals (such as delavirdine, indinavir, nevirapine, ritonavir), astemizole, carbamazepine, cisapride, methyl-prednisolone, paclitaxel, statins (but see Lipid regulating drugs , (p.l086)), and vinca alkaloids. More study is needed. 

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