DNA Polymerase A Processive Molecular Machine

9 Keck, J. L. and Berger, J. M., DNA replication at high resolution . Chemistry Biology 2000, 7, R63-R71. 

Cell division involves the replication of the cellular DNA. The DNA double helix is separated into the two individual strands and each one is used as a template to assemble nucleotide-by-nucleotide, a complementary strand resulting in a copy of the original DNA double helix. The enzyme that does this job, DNA polymerase, is one of the most accurate and remarkable pieces of molecular machinery 

The DNA replication process begins at origin points in the parent DNA strand which are targeted by DNA binding proteins resulting in the separation of the strands and the initiation of the replication fork complex via the helicase enzyme. The origin points tend to be A-T rich regions because of 

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