DNA minor groove binding

W. Wierenga "DNA-Minor Groove Binding Anticancer Agents" in Cytotoxic Mnticancer Drugs Models and Conceptsfor Drug Discovey and Development, Kluwer Academic PubHshers, Boston, Mass., 1992, p. 105. 

Schumacher, M.A., et al. Crystal structure of Lac 1 member, PurR, bound to DNA minor groove binding by a helices. Science 266 763-770, 1994. 

DNA Minor Groove Binding - Compare AAA and CCC Double Helix... 

Mann and coworkers have synthesized a new class of head-to-head bisbenzimidazoles 31 as DNA minor groove binding agents [41]. This new class of 6,6 -bisbenzimidazoles 31 was synthesized in moderate yields by the condensation of 3,3, 4,4 -tetraaminobiphenyl 30 with requisite aromatic aldehyde in nitrobenzene imder reflux for 8-12 hours (Scheme 8). 

In the search for simpler analogues of netropsine and distamycin A, which are DNA minor groove binding antibiotics, pyrazoles (316) and (317) have been synthesized <89JOC428). The x-ray structure of (316) was reported. 

Mote, J., Jr., Ghanouni, P., and Reines, D.A. (1994) DNA minor groove-binding ligand both potentiates and arrests transcription by RNA polymerase II. Elongation factor SII enables readthrough at arrest sites. /. Mol. Biol, 236, 725-737. 

K.A., et al. (1993) Structure, DNA minor groove binding, and base pair specificity of alkyl- and aryl-linked bis(amidinobenzimidazoles) and bis(amidinoindoles). J. Med. Chem. 36 1746-1753. 

Marm, J., Baton, A., Opoku-Boahen, Y., Johansson, E., Parkinson, G., KeUand, L.R. and Neidle, S. (2001) A new class of s)tmmetric bisbenzimidazole-based DNA minor groove-binding agents showing antitumor activity. J. Med. Chem. 44 138-144. 

Paz, M.M., Das, A., and Tomasz, M., Mitomycin C hnked to DNA minor groove binding agents synthesis, reductive activation, DNA binding and cross-hnking properties and in vitro antitumor activity, Bioorg. Med. Chem., 7,2713,1999. 

Human leukemia cell lines Jurkat pharmacologic inhibitors DNA minor groove binding methylsulfonateester lexitropsin [MeOSO(2)(CH(2))(2)-J 58... 

Tentori L, Balduzzi A, Portarena I et al. Poly (ADP-ribose) polymerase inhibitor increases apoptosis and reduces necrosis induced by a DNA minor groove binding methyl sulfonate ester. Cell Death Differ 2001 8(8) 817-828. 

Energy Analysis of DNA Minor Groove Binding Reactions... 

There are also G4 ligands that bind at the grooves of quadruplexes, with structures similar to those for duplex DNA minor groove binding ligands [76, 77]. 

Jain AK, Bhattacharya S (2011) Interaction of G-quadruplexes with nonintercalating duplex-DNA minor groove binding ligands. Bioconjugate Chem 22 2355-2368... 

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