DNA damaging properties

The bioreductively-activated, hypoxia-selective DNA-damaging properties found in tirapazamine are not uniqne to this nitrogen heterocycle. Analogous properties have been observed for quinoxaline di-A-oxides snch as 99 and In addi-... 

Burcham, P.C. (1998). Genotoxic lipid peroxidation products their DNA damaging properties and role in formation of endogenous DNA adducts. Mutagenesis 13 287-305. Cameron, S. (2006). Snakes and spiders. In The Toxicology Handbook for Clinicians (C.R. Harris, ed.), pp. 183-93. Mosby, Elsevier, Philadelphia. 

Burcham, P.C. (1998) Genotoxic lipid peroxidation products their DNA damaging properties and role in formation of endogenous DNA adducts. 

In addition to their inherent self-sustaining properties, brain tumor stem cells may be more resistant to chemotherapy and radiation therapy than other tumor cells. Bao et al. (2006) found glioma stem cells (CD133+) were relatively radioresistant compared to CD133- tumor cells and preferentially activated the DNA damage checkpoint response. This relative resistance to standard treatment approaches of tumor stem cells compared to the majority of other cells within a tumor may underlie our current inability to cure patients with aggressive brain tumors such as glioblastoma. 

DNA damaging mutagenic, elastogenic and cell-cell communication inhibitory properties of y-oryzanoL . 1 Toxicol Sci. 16 191-202. 

To understand the overall biological activity of quinoid compounds, it is necessary to study the chemical properties of these substances. Inasmuch as the cellular damage that is induced by quinones resembles that seen after radiolysis, the most prominent reactions involving quinones are probably DNA damage and generation of oxygen free radicals. 

Some examples will be seen in later sections of carcinogens that seem not to require metabolic activation to electrophiles, and which do not possess significant electrophilic properties themselves these agents appear not to be involved in the initial DNA-damaging event, but rather at later stages of the neoplastic process. 

Its genotoxic properties have received little attention. DNA damage has been observed in treated mammalian cells, but it is not mutagenic in bacteria and does not cause chromosomal damage in cultured mammalian cells or dominant lethal effects in mice. 

---