DNA damaging chemotherapy

Poly (ADP-ribose) polymerase-1 (PARP-1) facilitates the repair of DNA strand breaks (Calabrese et al, 2004). Inhibiting PARP-1 increases the cytotoxicity of DNA-damaging chemotherapy and radiation therapy in vitro. But classical PARP-1 inhibitors have limited clinical utility. AG14361 is, to our knowledge, the first high-potency... 

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