DMSO Solubility and Precipitation

This section focuses on compound precipitation from compound in DMSO stock solutions. This is an issue of compound solubility in DMSO as well as wet DMSO. 

This author has not heard any reports at compound management conferences of significant problems initially dissolving compounds in dry DMSO. In the author s experience initial solubilization of compounds in DMSO is seldom a problem. At the author s Pfizer lab over 40 000 compounds were dissolved in DMSO at a 60 mM concentration. Problems dissolving a wide range of structures were so few that they were not worth tracking. However, virtually none of these 40000 compounds dissolved were crystalline. 

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