Diversity evolutionary genomics

Burroughs AM, Allen KN, Dunaway-Mariano D et al (2006) Evolutionary genomics of the HAD superfamily understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes. J Mol Biol 361 1003-1034... 

By virtue of their long evolutionary history, as weU as of their capacity to bind RNA, ATP, and other small molecules such as amino acids, the aaRSs have been recruited to carry out many diverse alternative functions in cells (4) (Fig. 4a). One such function includes capitalizing on its aminoacylation function to proofread tRNA processing and maturation in the nucleus that occurs before tRNA export to the cytoplasm for protein synthesis. In addition, aminoacylation of tRNA-like structures, such as the 3 -end of viral genomes in plants and tmRNA in Escherichia coli, is important for viral replication and for ribosome recycling, respectively. 

The phylogenetic analysis of known coronins presents a comprehensive overview of this gene family and lays a foimdation to advance studies on their distribution, structure and functional diversity in other species. The knowledge of evolutionary relationships should facilitate comparative genomic studies that will help to elucidate the fundamental cellular roles of coronins and rationalize their apparent absence from plants, which are also distinguished by their exceptionally high ratio of monomeric to filamentous actin. The diversity of coronins in unicellular organisms... 

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