Distribution, Storage and Excretion

Homeostasis The mechanisms ensuring optimal absorption, distribution, storage and excretion of an element over a range of intakes constitute an effective system of homeostatic regulation for that particular element. 

Distribution, Storage and Excretion. Hydrocarbons in each of the aliphatic and aromatic fractions are expected to be distributed throughout tissues and organs following absorption. Preferential distribution to fatty tissues occurs especially with aliphatic hydrocarbons. Ingested or inhaled volatile aliphatic and aromatic hydrocarbons in the HC5-EC8 and EC5-EC9 fractions can be eliminated in exhaled breath as unchanged parent compound. Metabolic elimination of aromatic hydrocarbons in each EC fraction predominately occurs via oxidative metabolic pathways involving... 

The absorption, distribution, storage, and excretion of tetrachloroethylene are largely determined by its lipophilic nature. The blood/air partition coefficient estimated for humans is 10-20, the fat/air partition coefficient is 1,450-1,638, and the fat/blood partition coefficient is 125-159 (Byczkowski and Fisher 1994 Gearhart et al. 1993 Ward et al. 1988). Therefore, tetrachloroethylene is readily taken up by blood and is then distributed to fatty tissues where it is retained with a half-life of about 55 hours. The affinity of tetrachloroethylene for fat also results in its translocation into milk (Byczkowski and Fisher 1994). 

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