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Distribution, matrix drug delivery system

Because absorptivity of drugs depends on physicochemical properties, such as diffusivity and distribution coefficient of the matrix, selection of the matrix is especially important for the development of highly efficient drug delivery systems. In general, requirements for these drugs are... [Pg.1104]

Table 15.4 presents some of the intravaginal veterinary drug delivery systems for bovine estrus synchronization. These devices contain progesterone uniformly distributed throughout the silicone matrix. As mentioned before, the initial progesterone load is higher than hormone solubility in the matrix to meet the therapeutic requirements. [Pg.230]

Drug release from biodegradable polymer microparticles is determined by the polymer degradation kinetics, structural features of the microparticles, and distribution of the drugs within the particle matrix. The ultimate goal of microparticle systems in the controlled drug delivery is to achieve readily tunable release profiles, which has been pursued in various perspectives. [Pg.2322]

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See also in sourсe #XX -- [ Pg.8 ]



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