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Distribution, matrix drug delivery

Drug release from biodegradable polymer microparticles is determined by the polymer degradation kinetics, structural features of the microparticles, and distribution of the drugs within the particle matrix. The ultimate goal of microparticle systems in the controlled drug delivery is to achieve readily tunable release profiles, which has been pursued in various perspectives. [Pg.2322]

Because absorptivity of drugs depends on physicochemical properties, such as diffusivity and distribution coefficient of the matrix, selection of the matrix is especially important for the development of highly efficient drug delivery systems. In general, requirements for these drugs are... [Pg.1104]

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Distribution, matrix drug delivery system