Dissonant patterns

The positive charge (+) is placed at the carbon attached to an E class functional group (e.g., =0, -OH, -Br) and the TM is then analyzed for consonant and dissonant patterns by assigning alternating polarities to the remaining carbons. In a consonant pattern, carbon atoms with the same class of functional groups have matching polarities, whereas in a dissonant pattern, their polarities are unlike. If a consonant pattern is present in a molecule, a simple synthesis may often be achieved. 

Dissonant patterns One E class group is bonded to a carbon with a positive charge, whereas the other E class group resides on a carbon with a negative charge. 

A particularly important set of beliefs is the idea that a given substance is addictive. Once a behavioral pattern is conceptualized as an addiction, with the concomitant causal beliefs, it may change dramatically. An especially important belief is that addiction is, if not irresistible, at least very hard to resist, almost amounting to compulsive desire. Hence, to the causal beliefs about the effects of drug taking on the addict s body and socioeconomic status, we must add causa) beliefs about the effect of addiction on his will—specifically, on the ability to quit. Two opposite beliefs about this effect may have the same impact on behavior. Some addicts use their (usually self-deceptive) belief that they can quit at any time as an excuse for not quitting. Others use their (equally self-deceptive) belief that they are unable to quit as an excuse for not quitting. The belief that one is addicted may reinforce the addiction by the mechanism of dissonance reduction ... 

The dissonant charge pattern for 2,5-hexanedione exhibits a positive (-1-) polarity at one of the a-carbons, as indicated in the acceptor synthon above. Thus, the a-carbon in this synthon requires an inversion of polarity Umpolung in German) from the negative (-) polarity normally associated with a ketone a-carbon. An appropriate substrate (SE) for the acceptor synthon is the electrophilic a-bromo ketone. It should be noted that an enolate ion might act as a base, resulting in deprotonation of an a-halo ketone, a reaction that could lead to the formation of an epoxy ketone Darzens condensation). To circumvent this problem, a weakly basic enamine is used instead of the enolate. 

There is no simple way to disconnect the TM shown below (dissonant charge pattern). However, the presence of a 1,6-dioxygenated compound suggests opening of a six-member ring. A variety of cyclohexene precursors are readily available via condensation and Diels-Alder reactions or via Birch reductions of aromatic compounds. 

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