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Dissociation, 369 esters

Differences In hydrolysis characteristics are used in analytical test procedures to Identify the easily dissociated esters by polymer and tltratable acidity, amd the less reactive by total acidity procedures. Total hydrocarbon content is determined by carbon analysis,and uncombined by the aniline sulfate procedure. [Pg.304]

Figure 3-8 a) The dissociation of substituted benzoic acids (X = substituent), and b) the hydrolysis of benzoic acid methyl esters. [Pg.181]

FIGURE 20 4 The mecha nism of acid catalyzed ester hydrolysis Steps 1 through 3 show the formation of the tetrahedral intermediate Dissociation of the tetrahe dral intermediate is shown in steps 4 through 6... [Pg.850]

Once formed the tetrahedral intermediate can revert to starting materials by merely reversing the reactions that formed it or it can continue onward to products In the sec ond stage of ester hydrolysis the tetrahedral intermediate dissociates to an alcohol and a carboxylic acid In step 4 of Figure 20 4 protonation of the tetrahedral intermediate at Its alkoxy oxygen gives a new oxonium ion which loses a molecule of alcohol m step 5 Along with the alcohol the protonated form of the carboxylic acid arises by dissocia tion of the tetrahedral intermediate Its deprotonation m step 6 completes the process... [Pg.851]

The reaction of ammonia and amines with esters follows the same general mech anistic course as other nucleophilic acyl substitution reactions (Figure 20 6) A tetrahe dral intermediate is formed m the first stage of the process and dissociates m the second stage... [Pg.857]

In base the tetrahedral intermediate is formed m a manner analogous to that pro posed for ester saponification Steps 1 and 2 m Figure 20 8 show the formation of the tetrahedral intermediate m the basic hydrolysis of amides In step 3 the basic ammo group of the tetrahedral intermediate abstracts a proton from water and m step 4 the derived ammonium ion dissociates Conversion of the carboxylic acid to its corresponding carboxylate anion m step 5 completes the process and renders the overall reaction irreversible... [Pg.865]

The characteristic reaction of acyl chlorides acid anhydrides esters and amides is nucleophilic acyl substitution Addition of a nucleophilic reagent Nu—H to the carbonyl group leads to a tetrahedral mtermedi ate that dissociates to give the product of substitution... [Pg.874]

The intermediate m hydrogenation formed by reaction of the unsaturated ester with the hydrogenated surface of the metal catalyst not only can proceed to the saturated fatty acid ester but also can dissociate to the original ester having a cis double bond or to its trans stereoisomer Unlike polyunsaturated vegetable oils which tend to reduce serum cholesterol levels the trans fats produced by partial hydrogenation have cholesterol raising effects similar to those of saturated fats... [Pg.1074]

The physical properties of cyanoacetic acid [372-09-8] and two of its ester derivatives are Hsted ia Table 11 (82). The parent acid is a strong organic acid with a dissociation constant at 25°C of 3.36 x 10. It is prepared by the reaction of chloroacetic acid with sodium cyanide. It is hygroscopic and highly soluble ia alcohols and diethyl ether but iasoluble ia both aromatic and aUphatic hydrocarbons. It undergoes typical nitrile and acid reactions but the presence of the nitrile and the carboxyUc acid on the same carbon cause the hydrogens on C-2 to be readily replaced. The resulting malonic acid derivative decarboxylates to a substituted acrylonitrile ... [Pg.225]

Acrylic acid is a moderately strong carboxylic acid. Its dissociation constant is 5.5 x 10. Vapor pressure as a function of temperature is given in Table 4 for acrylic acid and four important esters (4,16—18). The lower esters form a2eotropes both with water and with their corresponding alcohols. [Pg.150]

Both the carboxyl and the mercapto moieties of thioglycolic acid are acidic. Dissociation constants at 25°C are for pR, 3.6 pi, 10.5. ThioglycoHc acid is miscible ia water, ether, chloroform, dichloroethane and esters. It is weakly soluble ia aHphatic hydrocarbons such as heptane, hexane. Solvents such as alcohols and ketones can also react with thioglycolic acid. [Pg.1]

Appllca.tlons. MCA is used for the resolution of many classes of chiral dmgs. Polar compounds such as amines, amides, imides, esters, and ketones can be resolved (34). A phenyl or a cycloalkyl group near the chiral center seems to improve chiral selectivity. Nonpolar racemates have also been resolved, but charged or dissociating compounds are not retained on MCA. Mobile phases used with MCA columns include ethanol and methanol. [Pg.100]

When the combination X,Yor X, Y is of the capto-dative type, as is the case for an alkoxy and an ester group, the enthalpy of bond dissociation is 10-15 kcal lower than when all four groups are electron-attracting. When the capto-dative combination CN/NR2 occupies both the X, Y and the X, Y positions, the enthalpy for dissociation of the C(3)—C(4) bond is less than lOkcal/mol. ... [Pg.695]

Substrate and product inhibitions analyses involved considerations of competitive, uncompetitive, non-competitive and mixed inhibition models. The kinetic studies of the enantiomeric hydrolysis reaction in the membrane reactor included inhibition effects by substrate (ibuprofen ester) and product (2-ethoxyethanol) while varying substrate concentration (5-50 mmol-I ). The initial reaction rate obtained from experimental data was used in the primary (Hanes-Woolf plot) and secondary plots (1/Vmax versus inhibitor concentration), which gave estimates of substrate inhibition (K[s) and product inhibition constants (A jp). The inhibitor constant (K[s or K[v) is a measure of enzyme-inhibitor affinity. It is the dissociation constant of the enzyme-inhibitor complex. [Pg.131]

Enzyme reaction kinetics were modelled on the basis of rapid equilibrium assumption. Rapid equilibrium condition (also known as quasi-equilibrium) assumes that only the early components of the reaction are at equilibrium.8-10 In rapid equilibrium conditions, the enzyme (E), substrate (S) and enzyme-substrate (ES), the central complex equilibrate rapidly compared with the dissociation rate of ES into E and product (P ). The combined inhibition effects by 2-ethoxyethanol as a non-competitive inhibitor and (S)-ibuprofen ester as an uncompetitive inhibition resulted in an overall mechanism, shown in Figure 5.20. [Pg.135]


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See also in sourсe #XX -- [ Pg.403 ]




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Phosphate esters dissociation constants

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