Disseminated intravascular incidence

Severe skin rashes appear to be the major concern with lamotrigine use. The incidence of rash is greater in children than in adults. Other adverse effects are similar to those of drugs with the same mechanism of action, such as cerebellovestibular changes leading to dizziness, diplopia, ataxia, and blurred vision. Disseminated intravascular coagulation has been reported. 

TOXICITY Common adverse effects when lamotrigine is added to another antiseizure drug are dizziness, ataxia, blurred or double vision, nausea, vomiting, and rash. A few cases of Stevens-Johnson syndrome and disseminated intravascular coagulation have been reported. The incidence of serious rash in children (-0.8%) is higher than in adults (0.3%). 

Hematologic Historically, there was concern that prothrombin complex concentrates were associated with thrombotic events such as stroke, myocardial infarction, pulmonary embolism, deep venous thrombosis, and disseminated intravascular coagulation. These events resulted mainly from the use of prothrombin complex concentrates as source of factor IX in patients with hemophilia B, and in particular after surgery, but the reported incidence is low and there is considerable evidence that the risk of thrombosis has been minimized with current prothrombin complex concentrates by reduced use of activated factors and the... 

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