Dispersibility dissociation constant

The mobile phase is interesting in that the water is buffered appropriately to complement the dissociation constants of the solutes. A mixture of methanol and acetonitrile is employed, the acetonitrile being used to increase the dispersive interactions in the mobile phase. The reason for the particular solvent mixture is not clear and it would appear that the separation might be achieved equally well by using a stronger solution of methanol alone or a more dilute solution acetonitrile alone. There is no particular advantage to one solvent mixture over another except for the fact that waste acetonitrile produces greater solvent disposal problems than methanol. 

In the inset of Fig. 6c, the calculations were repeated for the same values of the parameters, but a stronger double layer (N= 2X1017 sites/m2, Ku = 1.0 M). The ion-dispersion forces have in this case only a minor effect, and the interaction can be well approximated by the traditional Poisson-Boltzmann approach, with slightly modified parameters (density of sites, dissociation constant). 

These chelating agents have frequently been used as probes for the interactions taking place at the catalytic site. Vallee and co-workers (133,232,233,246-248) have utilized the optical rotatory dispersion curves of the complexes, whereas Yonetani (97,120) and Sigman (249) have studied the changes in the absorption spectrum. By the latter method dissociation constants have been measured for a number of binary substrate and inhibitor complexes as well as some ternary inhibitor complexes. The interaction of LADH and a spin-labeled analog of 1,10-phenanthroline has also been studied (141)-Heterocyclic nitrogen bases such as imidazole have been found (244, 60-252) to form both binary complexes with LADH and ternary... 

Roy SD, Flyim GL (1989) SolubUity behavior of narcotic analgesics in aqueous media solubilities and dissociation constants of morphine, fentanyl and sufentanil. Pharm Res 6(2) 147-151 Rubinstein M, Colby RH (2003) Polymer physics. Oxford University Press, New York Rumondor ACF, Taylor LS (2010) Effect of polymer hygroscopicity on the phase behavior of amorphous solid dispersions in the presence of moisture. Mol Pharm 7(2) 477-490 Rumondor ACF, Marsac PJ, Stanford LA, Taylor LS (2009) Phase behavior of poly(vinylpyrrolidone) containing amorphous solid dispersions in the presence of moisture. Mol Pharm 6(5) 1492-1505... 

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