Disorders of platelet function

Table 1 Classification of Congenital Disorders of Platelet Function...

RaoAK. Congenital disorders of platelet function. Hematol Oncol Clin N Amer. 1990 4 65-86. 

The assay, introduced by Bom (1962a,b), has become a standard method in clinical diagnosis of platelet function disorders and of aspirin intake. Furthermore, the method is used in the discovery of antiplatelet drugs with the advantage of rapid measurement of a functional parameter in intact human platelets. However, processing of platelets during the preparion of PRP, washed or filtered platelets from whole blood results in platelet activation and separation of large-size platelets. 

The hemophilias are a group of related, usually inherited, bleeding disorders. Inherited bleeding disorders include abnormalities of coagulation factors as well as platelet function. When the term hemo-... 

Studies by Scmtton et. al. and Stormoiken and his associates, have shown compromised functional response to epinephrine in apparently normal individuals (52,53). Weiss et. al. have described secretion defects from patients with bleeding disorders (54). White et. al. have followed functional response of platelets of patients with diabetes and Hermasky-Pudlak Syndrome (HPS) whose platelets lack dense bodies. Platelets of patients with HPS exhibit compromised response to the action of agonists (55). Hardisty et. al., and Ware and associates, have provided further evidence for altered signal transduction mechanisms. These and other studies seem to suggest that an impaired intracellular calcium flux may be the chief cause of platelet dysfunction (56-58, discussed in other chapters). 

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