Diselenolane-3-pentanoic Acid

2- Diselenolane-3-pentanoic acid, in which the sulphur atoms of a-lipoic acid are replaced with selenium, displayed markedly different antioxidant properties when compared to a-lipoic acid (Matsugo et al. 1997). l,2-Diselenolane-3-pentanoic acid was unable to inhibit protein oxidative modification of human low density hpoprotein and bovine serum albumin induced by copper ion or hydroxyl radical, whereas a-lipoic acid showed significant protection. However, l,2-diselenolane-3-pentanoic acid was able to inhibit the formation of Hpid peroxidation products in low density hpoprotein after oxidation by copper, while a-hpoic acid did not. 

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The lipoic analog, l,2-diselenolane-3-pentanoic acid 186, protects human low density lipoprotein against oxidative modification mediated by copper ions <1997BBR819>. Moreover, this compound has been investigated for its ability to inhibit the activity of the mammalian pyruvate dehydrogenase complex (PDC) <1999MI685>. 

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