Disease states febrile state

Ascorbic acid, a water-soluble vitamin (1(X) to 250 mg p.o. daily), is indicated in the treatment of frank and subclinical scurvy in extensive bums, delayed fracture or wound healing, postoperative wound healing severe febrile or chronic disease states and in prevention of ascorbic acid deficiency in those with poor nutritional habits or increased requirements. In addition, ascorbic acid has been used for potentiation of meth-enamine in urine acidification and as an adjunctive therapy in the treatment of idiopathic methemoglobinemia. 

Over the last 40 yr, studies of tissues from individuals with rheumatoid arthritis (RA) have revealed that Cu concentrations change in this disease state. Results reported from 1938 to 1953 are presented in Table 5.1. Heilmeyer and Stuwe [6] were first to report a total plasma Cu increase in men and women with active RA which returned to normal with remission. These changes in TS Cu were not related to sex but were most pronounced in active febrile disease and correlated with a decrease in haemoglobin and an increase in erythrocyte sedimentation rate (ESR) [7]. This arthritic disease-related alteration of serum Cu was con-... 

Classic beri-beri, rarely seen in the United States and Europe, except in alcoholism (P4), is endemic in the Far East because of the prevalent diet of decorticated rice (F6). It occurs in two forms wet beri-beri, characterized by edema and cardiovascular symptoms (G6), and dry beri-beri with peripheral neuritis, paralysis, and atrophy of the muscles. Conditions which may predispose to deficiency by increasing thiamine requirements are pregnancy (see section 2.4), and lactation, hyperthyroidism, malignant disease, febrile conditions, increased muscular activity, high carbohydrate diets, and parenteral administration of glucose solutions. A constant supply of thiamine is required for optimal nutrition because storage in the liver and elsewhere is limited. Thiamine is synthesized by bacteria in the intestinal tract of various animals, but this is not a dependable source for man. 

The reported incidence in the United States since 1967 has been fewer than 200 cases per year. This compares with 2,291 cases reported in 1939 and more than 1,100 cases per year during the 1940s.1718 The decline in incidence may be due to a declining interest in rabbit hunting, less recognition of the disease by physicians, or inadvertent cure of the disease by physicians who treat febrile patients with aminoglycoside antibiotics.13... 

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