Disease-associated genetic variations

Genome-Wide Association Studies Scanning of a human genome biocomputationaUy to associate genetic variations to specific diseases, drug reactions, and other relevant issues. 

Our own data may summarized as follows. To benchmark the mining our method and also to provide access to information of medical interest, study focused on a subset of 500 human genes, called disease-associated genes, because experimental data on genetic variation and trait associa-... 

Hoehe, M. R., Kopke, K, Wendel, B., et al. (2000) Sequence variability and candidate gene analysis in complex disease association of mu opioid receptor gene variation with substance dependence. Hum. Mol. Genet. 9, 2895-2908. 

Fig. 10.8 Absolute genetic variation (AGV) and relative genetic variation (RGV) between Alzheimer s disease and vascular dementia associated with bigenic, trigenic, and tetragenic clusters of Alzheimer s disease (AD)-related genes. APOE, apolipoprotein E PS, presenilin. (Adapted from refs. 12,19,20, and 59.)...

Carbonell, J., Allen, R., Kalsi, G., et al. (2003) Variation in the DCPl gene, encoding the angiotensin converting enzyme ACE, is not associated with increased susceptibility to Alzheimer s disease. Psychiatr. Genet., 13, 47-50. 

Kehoe PG, Russ C, Mcllory S, et al. Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease. Nat Genet 1999 21 71-72. 

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