Discovery of Aldol Reaction Mediated by Boron Enolates

Discovery of Aldol Reaction Mediated by Boron Enolates 

the background of ho v we first conceived the idea of using boron enolate (vinyloxyboranes) in aldol reactions is described. At the beginning of the 1970s, several reactions vere being screened by utilizing characteristics of alkylthioboranes based on the concept of elements in combination, i.e. t vo elements in combination, create a novel reactivity different from vhen 

Modem Aldol Reactions. Vol. 1 Enolates, Organocatalysis, Biocatalysis and Natural Product Synthesis. Edited by Rainer Mahrwald 

Copyright 2004 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim ISBN 3-527-30714-1 

Unexpected formation of / -hydroxy thioester 4 on reaction of ketene 1 with thioborane 2. 

---