Discoveries and Applications of Glycan Arrays

Genomics Research Center, Academia Sinica, Taipei, Taiwan 

The traditional methods of evaluating the interactions of glycans and glycan-binding proteins are based on isothermal titration calorimetry, surface plasmon resonance (SPR), and enzyme-linked lectin assays. Recently, glycan arrays have been developed as a 

Glycochemical Synthesis Strategies and Applications, First Edition. 

Edited by Shang-Cheng Hung and Medel Manuel L. Zulueta. 

Due to the structural complexity of carbohydrates, preparation of structurally well-defined carbohydrates with broad diversity is a key issue for glycan array development. Because it is difficult to obtain sufficient quantities of glycans from natural sources, chemical or chemoenzymatic methods or even pure enzymatic methods have been used to address this deficiency. The recent advances in carbohydrate syntheses that are described in other chapters of this book have greatly reduced the labor for glycan preparation. 

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