Discover Navigator

The third edition contains major improvements over the previous two editions. I have updated references. Each reaction is now supplemented with two to three representative examples in synthesis to showcase its synthetic utility. As Emil Fischer stated Science is not an abstraction but as a product of human endeavor it is inseparably bound up in its development with the personalities and fortunes of those who dedicate themselves to it. To that end, I added biographical sketches for most of the chemists who discovered or developed those name reactions. Furthemore, I have significantly beefed up the subject index to help the reader navigate the book more easily. 

In 1419, at the beginning of Portuguese explorations, Joao Gonsalves Zarco, Tristao Vaz Teixeira, and Bartolomeu Perestrelo discovered an island in the middle of the Atlantic and which they named Madeira. The three Captains had received special privileges from Infante D. Hen-rique (Henry, the Navigator) and immediately started to cultivate the lands with wheat, vines, and sugarcane (Stevenson, 2005). 

Lipinski, C. A., Hopkins, A. Navigating chemical space for biology and medicine, Nat. Rev. Drug Discov. 2004, 432, 855-861. 

Fig. 1.3 Jules C. Dumont d Urville (1790-1842) was a French naval officer and navigator who led the French Naval Expedition to Antarctica from 1837 to 1840. He was an experienced explorer who had worked in the eastern Mediterranean Sea followed by two expeditions to map the coasts of Australia and New Zealand and to map variations of the magnetic field in the South Pacific euid the Southern Ocean. He used two ships (Astrolabe and Zelee) in eui attempt to find the magnetic pole in Antarctica Although he failed to achieve that objective, he named Adelie Land along the coast of East Antarctica after his wife and discovered two large islands off the coast of the Antarctic Peninsula (Photo by the Scott Polar Research Institute, University of Cambridge, used here with permission)...

The claim to Adelie Land which Dumont d Urville had discovered was not recognized until 1926 because it was not clear whether d Urville or Wilkes had actually seen it first. Finally, on January 20 of 1950, a group of scientists of the French Polar Expedition landed on the Adelie coast to set up a base which was named Dumont d Urville in honor of the famous navigator and explorer (Stonehouse 2002). 

Bajorath J, Peltason L, Wawer M, et al. Navigating structure-activity landscapes. Drug Discov Today 2009 14 698-705. 

Admiral, or that those have done who published his Four Navigations in attributing the discovery of this continent to himself, without mentioning anyone but himself. Owing to this, all the foreigners who write of these Indies in Latin, or in their own mother-tongue, or who make charts or maps, call the continent America, as having been first discovered by Americo. 

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