Disaccharide permeability

Chitobiose, a disaccharide of glucosamine, possesses two amino functions, at C-2 and C-2. These amino groups reacted with aliphatic and aromatic diacicl chlorides to give linear polyamides (11),39 These polymers afforded transparent films, which showed high permeability, indicating probable utility as permeation-dialysis membranes (Scheme 5),... 

BLM is distributed and accumulated in certain tumors when administered systematically [34]. It is speculated that the disaccharide moiety is significant for the membrane permeability or molecular recognition at the nuclear membrane [8]. 

PoYSER and West [503] and Harris, Luscombe and Poyser [274] determined the relative activities of different carbohydrates injected locally in inhibiting the increase in vascular permeability caused by intradermally injected ovomucoid, dextran, dextrin, yeast mannan and z5miosan. With the exception of dihydroxyacetone, galactose, lactose, rhamnose and ribose many hexoses, pentoses, tricses and disaccharides were active. In a further study, Poyser and West [504] elucidated the structural and stereospecific features of topically administered sugars for potent inhibitory activity against intradermal responses to dextran. The monosaccharides most active as inhibitors contained the... 

T>-threo-ty e of structure in their cyclic forms (Fig. 1). The 6-membered ring structure of a sugar also seemed important for a potent antagonist, although the oin the ring is probably not essential for combination with the dextran receptor. The inhibitory activity of a disaccharide depends on the activities of its constituent monosaccharide units, but the type of linkage between the units is less important. Since the permeability response to intradermal histamine,... 

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