Diprophylline theophylline

Chamical Nama 7-(2,3-Dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-l H-purine-2,6-dione Common Nama (1,2-Dihydroxy-3-propyl)theophylline diprophylline... 

Common Name (l,2-Dihydroxy-3-propyl)theophylline Diprophylline Structural Formula ... 

Antiasthma. Theophylline and diprophylline are eliminated slowly by the neonate observe the infant for irritability or disturbed sleep. 

The xanthines used in nnedicine are quite a homogenous group as regards UV spectra. All the compounds listed (caffeine [002], pentoxifylline [006], diprophylline [1406], etofylline [1407], theobromine [1414], theophylline [1415]) have a good, constant absorption band at 272 2 nm e approximately 9000-10000 in methanol minimum 242 2 nm (see figure 10). 

Wenk, M. Eggs, B. Follath, F. Simultaneous determination of diprophylline, proxyphylline and theophylline in serum by reversed-phase high-performance liquid chromatography. J.Chromatogr., 1983, 276, 341-348... 

Caffeine, like theophylline, also undergoes extensive hepatic metabolism, principally by CYP1A2, and interacts with many drugs, but it has a wider therapeutic range. However, other xanthines may act differently (e.g. diprophylline does not undergo hepatic metabolism), so it should not be assumed that they all share common interactions. 

Xanthine derivatives Oral Aminophylline, Bamifylline, Bufylline, Choline theophyllinate, Diprophylline, Doxofylline, Etofylline, Etamiphylline camsilate, Heptaminol acefyllinate, Proxyphylline, Theophylline... 

Diprophylline is largely excreted unchanged by the kidneys, and probenecid inhibits its renal tubular secretion. Theophylline is largely cleared from the body by hepatic metabolism, and would therefore not be expected to be affected by probenecid. 

Based on the findings of this single-dose study, it would seem to be prudent to monitor serum diprophylline levels if probenecid is started or stopped. No special precautions are needed if theophylline and probenecid are given concurrently. 

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