Diphoterine® solutions French

A Clinical Study in a French Facility Water Versus DIPHOTERINE Solution... 

A third study was done in a French facility focusing on 5 predominant chanicals acrylates, 98 % sulfuric add, oleum, sodium hydroxide, and diethylaminoacrylate. The study involved 375 cases with 205 cases washed with water and 170 washed with DIPHOTERINE solution. When DIPHOTERINE solution washing was used as compared to water washing, there was a significantly (p <0.05) decreased incidence of lost work time (Table 4.12), a decreased incidence of longterm sequelae, and a nonsignificant (p < 0.1) trend for lesser needs to bum center consultations [249] (Table 4.12). 

An epidemiological study of 145 eye/skin splashes with a variety of chemical substances including acids, alkalis, oxidants, solvents, and glues self-reported by occupational physicians was conducted by the French INRS (Institut National de Recherche et de Security, or National Institute for Research and Safety) [250-252]. DIPHOTERINE solution was found to be efficacious for decontamination of acids and alkali eye/ skin splashes, and its combination with water washing did not improve efficacy [253, 254]. Outcome endpoints such as severity of chemical injury, lost work time, and requirement for treatment other than initial decontamination were all improved when DIPHOTERINE solution was utifized as the initial washing solution [250-252]. 

A second study was done in a French chemical facility where acid and sodium hydroxide splashes occurred. When DIPHOTERINE solution was utilized as the decontaminant solution, there was a decrease in the severity of chemical... 

Table 4.22 Results of a clinical study in a French facility, water versus DIPHOTERINE solution...

Diphoterine. Diphoterine is a French decontamination product inaniifactLired by Prevor Laboratory (Vlamondois, France) (Material Data and Safety Sheet, 2007). Unlike the other decontaminating systems discussed, Diphoterine was also designed to be used in decontaminating the eyes. It is supplied as an odorless, colorless, sterile solution in water (pH 7.4). It is classified as a slight dermal irritant (Jones et al., 1987) but a nonirritant in the eye as tested in the rabbit model (Clouzeau and Read 1990). 

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