Diphenylmethyl amine

Diphenylmethyl)amine is used as a convenient protected source of ammonia. ... 

Most mechanistic studies " have utilized lV,Al-diphenylmethyl-amine. With this substrate in the absence of oxygen, photochemical cyclization to the observable 312 (R = H, R = Me) is followed by disproportionation to the carbazole and to a tetrahydrocarbazole believed to be... 

N- [(4 -Methoxyphenyl) diphenylmethyl] amine (MMTr NR2) (4-CH30-C6H4)(C6H5)2C-NR2 (Chart 10)... 

Zur Reduktion von Diazo-Verbindungen zu Hydrazinen durch Natriumamalgam s.ds. Handb. Bd. X/4, S. 889. So erhalt man z.B. aus Diazoessigsaure Hydrazino-essigsaure, wahrend Diphenyl-diazomethan zu Diphenylmethyl-amin reduziert wird (mit Palladium als Katalysator erhalt man Diphenylmethan). 

A different approach is to attach a chiral auxiliary to the ester, and then react it with an achiral amine. This approach was used by d Angelo when diphenylmethyl-amine was added to 2-(l-p-naphthyl-l-methylethyl)-5-methylcyclohexyl but-2E-enoate 5.147), a menthol analog. High pressure s Michael addition (15 kbar) led to... 

A new stable sulfenylating reagent 3-phenylsulfenyl-2-GV-cyano-imino)thiazolidine 57 has been described. It reacts with amines or thiols to give sulfenamides or disulfides in excellent yields. a-Sulfenylation of carbonyl compounds also proceeds smoothly and if an optically active 4-diphenylmethyl substituent is attached to the thiazolidine ring (58), the cyclic (3-ketoester 59 can be sulfenylated in high yield with an ee of 96% to give the sulfide 60 <00SL32>. 

Tong, W.Q., Chin, T. F., and Guillory, J. K. 1991a. Microcalorimetric investigation of the complexation between 2-hydroxypropyl-fS-cyclodextrin and amine drugs with the diphenylmethyl functionality. 

The cascade in Figure 3.9, based on lysine, possesses unsymmetrical branches, its name is 8-Cascade ./V-(diphenylmethyl)acetamide[2-2,2] (2-oxo-3-azapropylidene 2-oxo-3-azaheptylidene)2 A -(te/- -butoxycarbonyl)amine A -(fer/-butoxycarbonyl)butyl-amine. 

Fig. 3.6 Privileged structures are scaffolds or substituents that often produce biologically active compounds for example, phenethyl-amines, diphenylmethyl and diphenylamine compounds (X = Cor N, respectively), tricyclic...

In many reactions the simple saturated nitrogen heterocycles—piperidine, pyrrolidine, piperazine, and morpholine—behave simply as secondary amines that happen to be cyclic. They do the sorts of things that other amines do, acting as nucleophiles in addition and substitution reactions. Morpholine, for example, is acylated by 3,4,5-trimethoxybenzoyl chloride to form the tranquillizer and muscle relaxant trimetozine, and N-methyl piperazine can be alkylated in an S l reaction with diphenylmethyl chloride to give the travel-sickness drug cyclizine. 

The use of amines to catalyze (asymmetric) epoxidation reactions was introduced by Aggarwal and co-workers in 2000 <2000JA8317>. (Y)-2-(Diphenylmethyl)pyrrolidine 69 was examined in the asymmetric epoxidation of a number of cycloalkenes (Table 6). Subsequently it was found that more consistent and reproducible results were obtained when... 

Nucleophilic displacement of the entire diphenylmethylsulfanyl group of 6-[(diphenylmethyl)-sulfanyl]purin-2-amine affords 9-ethylpurine-2,6-diamine (5) using ammonia in ethanol at high... 

A solution containing 6-[(diphenylmethyl)sulfanyl]-9-ethylpurin-2-amine (3 g, 8 mmol) in abs EtOH saturated with NH3 at — 40 °C (500 mL) was heated in a stainless steel bomb at 130 "C for 20 h. The solution was evaporated to dryness and the residue was triturated with Et O until solid. Crystallization of the crude material from EtOH afforded the product yield 1.2 g (85%) mp 225-226"C. 

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