Diphenyl piperidino

A mixture of 23 parts of the ethyl ester of 4 phenylisonipecotic acid and 15 parts of 2,2-diphenyl-4-bromobutyronitrile in 19 parts of xylene is heated for 24 hours at 100°-120°C and then cooled and filtered to remove the precipitate of the hydrobromide of the ethyl ester of 4-phenylisonipecotic acid. The filtrate is then extracted with dilute hydrochloric acid and the extract is rendered alkaline by addition of concentrated aqueous potassium hydroxide and extracted with ether. This ether extract is treated with gaseous hydrogen chloride. The resulting precipitate is collected on a filter. The hydrochloride of the ethyl ester of 2,2 diphenyl-4-(4 -carboxy-4 -phenyl-1 -piperidino) butyronitrile thus obtained melts at about 220.5-222°C. See Meperidine hydrochloride for synthesis of 4-phenyl-isonipecotic acid ethyl ester. 

A mixture of 84 parts of 3,3-diphenyl-3-cyanopropyl bromide, 41 parts of 4-piperidino4-pi-peridinecarboxamide, 64 parts of sodium carbonate, a small amount of potassium iodide and 1,200 parts of anhydrous toluene was stirred, and heated under reflux for 48 hours. At the end of this time the reaction mixture was allowed to cool to room temperature, and 500 parts of water were added. The resultant precipitate was removed by filtration, and triturated with diisopropyl ether. The crystalline material thus obtained was removed by filtration, and re-crystalli2ed from 320 parts of acetone, to give 1 -(3,3-diphenyl-3-cyanopropyl)4-piperidino-4-piperidinecarboxamide, melting at about 149°C to 150°C. 

CHj-CIUCgH,), (CH2) -N ) 3- (2,2-Diphenyl-ethyl j-5- ( 2-piperidino-ethyl)-... Prenoxdiazin 49... 

Chemical Name l-(3,3-Diphenyl-3-cyanopropyl)-4-piperidino-4-piperidinecarboxamide... 

Therapeutic Function Antiparkinsonian, Anticholinergic Chemical Name l,l-Diphenyl-3-piperidino-l-propanol hydrochloride Common Name Pridinol Ridinol Structural Formula ... 

Difluor-diphenyl-(2-methyl-piperidino)-phosphoranS J Unter Stickstoff werden 8,5 g (50 mmol) (2-Methyl-pi-peridino)-trimethyl-silan unter Riihren bei 50° zu 12,2 g (50 mmol) Diphcnyl-trifluor-phosphoran gegeben. Nach 2 Stdn. Erhitzen auf 80 wird der Kolbenriiekstand destilliert Ausbeute 14,7 g (93%) Sdp. 16670,05 Torr (6,67 Pa). 

SYNS KETONE, BROMOMETHYL 4-piPHENYLHYDROXYMETHYL)PIPERIDINO 4-PIPERIDINEMETHANOL, 1 -BROMOACETYL-a-a-DIPHENYL-... 

SYNS KETONE, CHLOROMETHYL 4-(DIPHENYL-HYDROXYMETHYL)PIPERIDINO 4-PIPERIDINEME-THANOL, 1-CHLOROACETYL-a-a-DIPHENYD... 

Dihydroxy-6,7-diphenyl- pteridine Piperidine 2,3 -Diphenyl-5 -piperidino-caibonyl-6-piperidino-carbonylamino and 2-amino-5,6-diphenyl-3-piperidinocarbonyi 451... 

The atropine-like activities of some compounds in which the asymmetric carbon atom is considerably closer to the amino group have been described. In l,l-diphenyl-3-piperidino-1-butanol, the carbon a to the nitrogen is asymmetric. In this case the (+) isomer seems to be more active than the (-) isomer. In... 

Diphenyl-5-hydroxy-1-melhoxy-carbonyl-5-methyl-3-piperidino-3167... 

Benzyl-piperazino)-6-cyano- - 914 3-Bromo-6-chloro-6-methyl- - 1459 3-Bromo-6-chloro-6-methyl- -4,5-dimethyl- 1459 6-Cyano-6-morpholino- - 908 6-Cyano-6-piperidino- - 908 - -4,5-diphenyl- 278 1-Ethinyl- -4,5-dimethyl- 1786 1-Formyl- -4,5-dimethyl- 1786 1-Hydroxymethyl- -4,5-dimethyl- 294... 

Diphenyl-2-piperidino-l,3-thiazolium-4-thiolat (R = CfIL Y = S)s<5i Eine Mischung von 1 g (3,6nnnol)... 

Oxo-l-thiono-l,2-diphenyl- 1037 Pentafluor-nitroso- 633 2-Phenyl- l-pyridyl-(2 - 1442 2-Phenyl- -1-sulfochlorid 169 sv H-2-Piperidino-l-hydroximino-l-lphenyl- 1328 2-Pyridyl-(2)-1 -pyridyl-14)- 597 Tctrachlor-2,2-bis-[4-chlor-phenyl]- 101... 

Piperidino- and 2-(dimethylamino)-5-phenyl-l,3-oxathiolium hydrogen sulfate, 13a and b, respectively, react with an excess of hydrazine hydrate in aqueous solution at room temperature by ring transformation to give 2-piperidino- and /V,/V -dimethyl-5-phenyT6//-l,3,4-thiadiazin-2-amine 12a and b, respectively.79,80 Compound 13a reacts in a similar fashion with phenylhy-drazine in dichloromethane to give 4,5-diphenyl-2-piperidino-4//-l,3,4-thiadiazine 14. 

Nitro-l-(l-chlor-phenyl)- 495 2-(l-Nitro-cyclohexyl)-l-pyridyl-(4)- 494 2-Nitro-1-furyl-(2)- 496 2-Nitro-l-pyridyl-(4)- 494 2-(4-Octyl-piperidino)-1-phenyl- 268 2-Oxo- l,2-bis- 4-methoxy-phenyl]- 601 2-Oxo- l,2-bis-[4-methyl-phenyl]- 601 2-Oxo-l,2-difuryl-(2)- 25 2-Oxo-1,2-diphenyl- 601... 

Ox o-2-(2,2-diphenyl- 1-methoxycarbonyl- vinyl)-1-phenyl- 713 1-Oxo-2-methyl- 205 l-Oxo-2-[pyridyl- 2)-methylen]- 464 3-(Piperidino-methyl)- 425... 

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