Diphenhydramine Hydrochloride Lotion

Hydrate item 6 in item 5 and disperse item 7 in the suspension. 

Dissolve item 2 in item 15 at 75°C dissolve camphor and perfume in alcohol and add to 

Add zinc oxide and calamine under high shear. Stir to cool. 

Add items 3 and 4 mix until dissolved using a shearing mixer. 

Maintain temperature at 75°C and gradually add item 1 continue mixing at 75°C for 15 

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The incidence of cutaneous reactions to topically applied diphenhydramine is difficult to asses (Emmett 1974). In one series, 12 of 117 cases of dermatitis medicamentosa seen in England, in one year were due to a lotion comprised of diphenhydramine hydrochloride and calamine (Caladryl) (Vickers 1961). All 12 were confirmed by positive patch tests, although in 10 instances, closed patch tests were... 

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