Dioleoyl-sn-glycero-3-phosphoethanolamine DOPE

Liposomes. Liposomes are vesicles that consist of an aqueous compartment enclosed in a phospholipids bilayer. As they lack proteinaceous components, liposomes are not immunogenic. A broad variety of cationic liposomes containing eventually modified lipids have been used to deliver pDNA and mRNA for therapeutic utilizations. These formulations are usually based on a cationic lipid such as l,2-dioleol-3-trimethylammonium propane (DOTAP) and a fusogenic lipid such as l,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) [22,23]. Despite their ease of production and efficacy in vitro for transfecting cultured cells, cationic liposomes face toxicity issues in vivo [24,25]. Meanwhile, their heterogeneous size... 

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