Dinitrosyl-diglutathionyl-iron complex

Cesareo E, Parker LJ, Pedersen JZ, Nuccetelli M, Mazzetti AP, Pastore A, Federici G, Caccuri AM, Ricci G, Adams JJ, Parker MW, Lo Bello M (2005) Nitrosylation of human glutathione transferase Pl-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo. J Biol Chem 280 42172 12180... 

Dinitrosyl-diglutathionyl-iron complex binds with extraordinary affinity to the active site of aU these dimeric enzymes, showing values of 10 -10 M [59, 60, 341], One of the glutathiones in the irmi complex binds to the enzyme G-site, whereas the other GSH molecule is lost and replaced by a tyrosine phenolate in the coordination of the ferrous ion [60] Thus the bound complex is a... 

Turella P, Pedersen JZ et al (2003) Glutathione transferase suptafamily behaves like storage proteins for dinitrosyl-diglutathionyl-iron complex in heterogeneous systems. J Biol Chem... 

De Maria, R, Pedersen, J.Z., Caccuri, A.M., Antonini, G., Turella, R, Stella, L., Lo Bello, M., Federici, G., and Ricci, G. (2003). The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily suggestion for an evolutionary pressure in the direction of the storage of nitric oxide. J. Biol. Chem. 278, 42283 2293. 

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