Dinitrosopiperazines

Kruger, F.W., Bertram, B. and Eisenbrand, G., "Investigation on 1 C02 Exhalation, Liver RNA Labeling and Isolation of Two Metabolites from Urine after Administration of [2,5- C]-Dinitrosopiperazine to Rats", Z. Krebsforsch, 1976, B5, 125-134. 

Multiple regression analysis on this data (29), with the addition of a values, gave no improvement on these relationships. For a series of dinitrosopiperazines, however, for which no correlation was detected with log P values alone, a fair correlation could be generated when a was included ... 

V,/V-Dinitrosopiperazine (409) exists in CH2C12 solution at 40°C as a mixture of the syn and anti forms in which the anti form predominates. The R value (1.5) of the anti form indicates its adoption of a boat form or a very flattened chair.333... 

Wear protective gloves, laboratory coat, and goggles. Perform all operations in the fume hood. Dissolve the dinitrosopiperazine (300 pg) in 50 mL of 3 M sulfuric acid (8.5 mL of concentrated sulfuric acid slowly added to 41.5 mL of cold water). Add potassium permanganate (2.4 g), swirl until dissolved, and allow to stand at room temperature for at least 8 hours. If necessary, add additional potassium permanganate to maintain the purple color of the solution. Neutralize the solution by cautiously adding 10% aqueous sodium hydroxide solution, and then add, while stirring, a saturated solution of sodium bisulfite (approximately 10 g of sodium bisulfite per 35 mL of water) until a colorless solution is formed. Wash into the drain with water.4. 

A few reactions of A-nitrosopiperazines have been reported recently. At least some such piperazines undergo facile transnitrosation and may be used to nitrosate other secondary bases or the like. For example, 2,6-dimethyl-1,4-dinitrosopiperazine (31) with piperidine (32), at pH 1.7 in the presence of sodium thiocyanate as catalyst, gave 2,6-dimethyl-4-nitrosopiperazine (33) and 1-nitrosopiperidine (34).763,cf-954... 

The rodential metabolism of 1,4-dinitrosopiperazine (37) gave A-nitrosodi-ethanolamine (38) (7%) and A-(2-hydroxyethyl)-A-nitrosoglycine (39) (30%), as well as other minor products.1225... 

SYNS DINITROSOPIPERAZIN (GERMAN) N,N -DINITROSOPIPERAZINE 1,4-DINITROSO-PIPERAZINE DNPZ NSC-339 USAF DO-36... 

DINITROSOPIPERAZINE see DVF200 N,N -DINTTROSOPIPERAZINE see DVF200 DINITROSORBIDE see CCK125... 

Piperazine with nitrous acid gave 1,4-dinitrosopiperazine, which was reduced by lithium aluminum hydride to 1,4-diaminopiperazine (1710) the electrochemical... 

Takano, T, Shirai, T, Ogiso, T, Tsuda, H., Baba, S., and Ito, N. (1982). Sequential changes in tumor development induced by 1,4-dinitrosopiperazine in the nasal cavity of F344 rats. Cancer Res 42, 4236 240. 

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