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Dimethylallyltryptophan synthase

Unsold lA, LiSM, Overproduction, purification and characterization of FgaPT2, a dimethylallyltryptophan synthase from Aspergillus fumigatus, Microbiology... [Pg.578]

Tsai H-F, Wang H, Gebler JC, Poulter CD, Schardl CL. The Claviceps purpurea gene encoding dimethylallyltryptophan synthase, the committed step for ergot alkaloid biosynthesis. Biochem Biophys Res Commun 216 119-125, 1995. [Pg.359]

Gebler JC, Poulter CD. Purification and characterization of dimethylallyltryptophan synthase from Claviceps purpurea. Arch Biochem Biophys 296 308-313, 1992. [Pg.424]

Chemoenzymatic synthesis. As for other indole positions, enzymatic prenylation appears to become competitive. Li employed the 4-dimethylallyltryptophan synthase FgaPT2 [211] and the 7-dimethylallyltryptophan synthase DM ATS [212] (both from Aspergillus fumigatus) to prenylate tryptophan derivatives (286) on the 100 nanomolar scale. In all cases shown in Scheme 54, yields >90% were obtained overnight, based on recovered starting material. As coupling partner, ammonium prenylpyrophosphate (8) was used as always. [Pg.117]

Scheme 54 Chemoenzymatic 4- and 7-prenylations of tryptophan derivatives 286 (FgaPT2 4-dimethylallyltryptophan synthase, DMATS 7-dimethylallyltryptophan synthase from Aspergillus fumigatus) by Li and co-workers [211, 212]... Scheme 54 Chemoenzymatic 4- and 7-prenylations of tryptophan derivatives 286 (FgaPT2 4-dimethylallyltryptophan synthase, DMATS 7-dimethylallyltryptophan synthase from Aspergillus fumigatus) by Li and co-workers [211, 212]...
The end-product repression involves probably the blockage of formation of specific synthases, at the time of a maximum rate of secondary biosynthesis. This results in a gradual decline in the level of the enzyme and a retardation of the product formation. The phenomenon was observed in gramicidin S synthases by Bacillus brevis (30), bacitracin synthase in Bacillus licheniformis (31), anhydrotetracycline hydratase by treptomyces aureofaci-ens (4), novobiocic acid synthase in Streptomyces niveus (35) or dimethylallyltryptophan synthase by ciaviceps (33). [Pg.115]

Four enzymes which are involved in the biosynthesis of the ergot alkaloids have now been isolated from Claviceps. The other three are 4-dimethylallyltryptophan synthase , chanoclavine-I cyclase , and agroclavine hydroxylase . ... [Pg.122]


See other pages where Dimethylallyltryptophan synthase is mentioned: [Pg.74]    [Pg.74]    [Pg.424]    [Pg.79]    [Pg.468]    [Pg.13]    [Pg.170]    [Pg.57]    [Pg.112]    [Pg.621]    [Pg.708]    [Pg.708]    [Pg.218]    [Pg.97]    [Pg.120]    [Pg.164]    [Pg.246]   
See also in sourсe #XX -- [ Pg.74 ]

See also in sourсe #XX -- [ Pg.117 ]

See also in sourсe #XX -- [ Pg.218 ]




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4-dimethylallyltryptophan

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