3.4- dimethyl-6-phenyl-4,5-dihydro

Chemical Name 2-[ [4-(l, 1-Di methylethyl)-2,6-dimethyl phenyl] methyl]-4,5-dihydro-lH-imidazole hydrochloride... 

Pyrazol 3-Amino-l-(2-brom-4,6-dimethyl-phenyl)-5-oxo-4,5-dihydro- E16a, 669 (Hydrazon-Bild./Red.-Cyclis.)... 

Dimethyl-phenyl)-4,4-dime-thyl-4,5-dihydro- E5, 819f. (H2N-CR2-CH2-OH + R-COOH)... 

Hydroxy 3-oxo-2,5-bis-[3,4-dimethyl-phenyI]-tetrahydrothiophen-l,l-dioxid3 21,4 g (60 mMol) 4-Hy-droxy-3-oxo-2,5-bis-[3,4-dimethyl-phenyl]-2,3-dihydro-thiophen-I,l-dioxid in 75 ml Eisessig, 75 ml Athanol und 75 ml THF werden auf 5° gekiihlt. Man fligt 19,5 g (0,3 g-Atom) Zinkstaub zu. Die erst griingelbe Farbe wird... 

Hydroxy-3-oxo- 2,5-bis-[3,4-dimethyl-pheny]]-tetrahydro- -1,1-dioxid aus 3-Hydroxy-4-oxo-2,5-bis-[3,4-dimethyl-phenyl]-4,5-dihydro-thiophen- 1,1-dioxid durch Reduktion mit Zn 710... 

Dihydro-5,7-dihydroxy-2,2-dimethyl-) -phenyl-2/f-1 -benzopyran-8-propanoic acid,... 

Phenyl-3,6-dihydro-l,3,4-oxadiazin-2-one (50) is a high temperature blowing agent used primarily for polycarbonates (qv). It is prepared by the reaction of a-hydroxyacetophenone and methyl carbazate (52), made from hydrazine and dimethyl carbonate (175) ... 

Isoxazolo[5,4-d]pyrimidine-4,6(5//,7//)-dione, la,3a-dihydro-5,7-dimethyl-3-phenyl- H NMR, 6, 619 <72JOC2983) Isoxazolo[5,4-d]pyrimidine-4,6(5//,7W)-dione, la,3a-dihydro-3-phenyl- H NMR, 6, 619 <72JOC2983)... 

Azodne-6,7-dicarboxylic add, 1,2-dihydro-1-phenyl-dimethyl ester NMR, 7, 660... 

Benzo[b]furan, 2,3-dihydro-2-phenyl-synthesis, 4, 697 Benzo[b]furan, 2,3-dihydroxy-tautomerism, 4, 37 Benzo[6]furan, 4,6-dimethoxy-acylation, 4, 606 Benzo[6]furan, 2,3-dimethyl-acetylation, 4, 606 bromination, 4, 605 photooxygenation, 4, 642 Benzo[b]furan, 5,6-dimethyl-2,3-diphenyl-applications, 4, 709 Benzo[b]furan, 1,3-diphenyl-vertical ionization potential, 4, 587 Benzo[b]furan, 2-ethoxy-5-hydroxy-synthesis, 4, 127... 

Indazole, 5,5-dimethyl-3-trifluoromethyl-4,5-dihydro-trichomonacidal activity, 5, 291 Indazole, 2-ethoxycarbonyl-reactions, 5, 269 Indazole, 3-fluoro-synthesis, S, 263 Indazole, 1-germyl-synthesis, 5, 236 Indazole, 1-glycosyl-synthesis, 5, 289 Indazole, 2-glycosyl-synthesis, 5, 289 Indazole, halo-reactions, S, 266 Indazole, 2-hydroxy-methylation, 5, 269 Indazole, 3-hydroxy-reactions, S, 264 Indazole, 6-hydroxy-diazo coupling, 5, 86 Indazole, hydroxyphenyl-synthesis, S, 288 Indazole, 3-iodo-synthesis, S, 241 Indazole, l-isopropyl-3-phenyl-reduction, 5, 243 Indazole, 3-mercapto-1 -substituted tautomerism, 5, 265 Indazole, methoxy-... 

The only triazole salt of type 83 that has been reported was obtained by the reaction of 2,3-dihydro-2,5-dimethyl-l-phenyl-l,2,4-triazole-3-thione (84) with methyl iodide to give 83 (R = R = Me, R " = Ph, R" = MeS). 

The absolute rate constants for the reaction of a variety of electrophilic free radicals with 4-(dimethylamino)-l,5-dimethyl-2-phenyl-l,2-dihydro-3//-pyrazol-3-one (aminopyrine) and l,5-dimefliyl-2-phenyl-l,2-dihydro-3//-pyrazol-3-one... 

Other examples of CN/CC replacement are observed in reactions of l-phenyl-pyrimidin-2(l//)-one with active methylene compounds, such as diethyl malonate and benzoylacetate, giving in good yield 2-oxo-l,2-dihydro-3-pyridinecarboxylate and 3-benzoylpyridin-2(l H)-one, respectively (84CPB2942, 87H2223) (Scheme 8). In a similar way 4,6-dimethyl-1-phenylpyrimidin-2( 1 //)-one, 4,6-dimethyl-1 -phenylpyrimidine-2( 1 //)-thione and 4,6-dimethyl-1 -phenyl-2-phenylimino-1,2-dihydropyrimidine yield with malonitrile 2-amino-4,6-dimethyl-3-pyridinecarbonitrile. In a similar way 2,3-diarylpyrimidin-4(3//)-thiones give with malonitrile CN/CC replacement (84H763) (Scheme 8). The reaction takes a similar course as described in Scheme 7. 

Curiously, 6-(chloromethyl)-4-methyl-2-methylene-3-phenyl-3-azabicyclo[4.1.0]hept-4-ene-l,5-dicarbonitrile (31), obtained from 4,4-bis(chloromethyl)-2,6-dimethyl-l-phenyl-1,4-dihydro-pyridine-3,5-dicarbonitrile, rearranges via 4-(chloromethyl)-7-methyl-2-methylene-l-phenyl-2, 5-dihydro-l//-azepine-3,6-dicarbonitrile (32) to yield the 4-(chloromethylene)-4,5-dihydro-1//-azepine 33 as the final product.127... 

Similarly, (A )-( )-3-(2-methoxymethyl-l-pyrrolidinyl)-l-phenylpropene118 121, after lithia-tion and addition of acetone, acidic hydrolysis and oxidation of the intermediate lactol, gives (5)-dihydro-5,5-dimethyl-4-phenyl-2(3/f)-furanone with 98% ee and 54% overall yield. Thus, these sequences constitute asymmetric homoaldol addition. 

Oxo-4,4-dimethyl-2-benzyl-4.5-dihydro- 228 5-Oxo-4-methyl-2-benzylidcn-2.5-dihydro- 228 5-Oxo-2-phenyl-4-benzyliden-4,5-dihydro- 228 5-Oxo-2-phenyl-4,5-dihydro- 228 2-Phenyl-4-ch orcarbonyl- 188 2-Phenyl-5-naphthyl-(l)- 591 2-Phenyl-5-naphthyi-(l)-2,3-dihydro- 591... 

Dimethylamino-1-methyl- 1,2-dihydro- 594 4-Dimethylamino-1-phenyl- 594 4-Dimethyl amino-1-phenyl-1,2-dihydro- 594... 

Benzenediamine (228) and diethyl dibromomalonate (229) gave ethyl 3-oxo-3,4-dihydro-2-quinoxalinecarboxylate (230) (MeOH, 20°C, 24 h 40%)." The same substrate (228) with ethyl a-bromoisobutyrate gave 3,3-dimethyl-3,4-dihydro-2(17i)-qumoxalinone (231) (Me2NCHO, NEtPr j, 110°C, 7 h 76%) or with methyl 2-bromo-2-phenylacetate gave 3-phenyl-3,4-dihydro-2(l//)-quinoxalinone (232) (KI, K2CO2, AcMe, reflux, 12 h then oily product, MeONa, PhH, reflux, 7 h 89%). ... 

Only one procedure has been reported recently within this category. Thus 7-chloro-l-methyl-5-phenyl-2,3-dihydro-lH-benzodiazepin-2-one 4-oxide (437) with dimethyl acetylenedicarboxylate in methylene chloride at 20° C for 3 days gave a separable mixmre of the primary tricyclic adduct, dimethyl lO-chloro-6-oxo-llb-phenyl-5,6,7, 1 lb-tetrahydroisoxazolo[2,3-t/] [ l,4]benzodiazepine-1,2-dicarboxylate (438), and its rearrangement product, 6-chloro-4-(2-methoxalyl-2-methoxycarbonyl-l-phenylvinyl)-l-methyl-3,4-dihydro-2(lT0-quinoxalinone (439) each product afforded 6-chloro-l-methyl-2(l//)-quinoxalinone (440) on refluxing in ethanol (see also Section 1.7.13). However, the final quinoxaline (440) was best obtained in 75% yield) by simply heating the initial substrate (437) and dimethyl... 

As in the preceding subsection, l,2-bis(benzenesulfonylimino)-4,5-dimethyl-benzene (598) and 2-phenylthiazolo[3,2-fl]quinolinium-l-olate (599) in dichloromethane at 20°C during 15 min afforded l,4-bis(benzenesulfonyl)-6,7-dimethyl-3-phenyl-3-(quinolin-2-ylthio)-3,4-dihydro-2(l//)-quinoxalinone (600) in almost quantitative yield. " ... 

Ethyl 6,7-dimethyl-3-oxo-3,4-dihydro-2-quinoxalinecarboxylate Ethyl 6,7-dimethyl-3-phenyl-2-quinoxalinecarboxylate Ethyl 2,3-dimethyl-6-quinoxahnecarboxylate... 

CN ( )-( )-l,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 3-phenyl-2-propenyl ester... 

CN [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-17/-pyrazol-4-yl)methylamino]methanesulfonic acid sodium salt... 

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