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1.3- Dimethyl-7-chloro-1 //-pyrazolo

Chloro-3-ethoxy-2-methyl-2//-pyrazolo[4,3-reacted with the sodium salt of dimethyl malonate in DMF to give (pyrazolo[4,3-c/]pyrimidin-7-yl)malonate (499) [88JAP(K)246377]. [Pg.128]

Chloro, 3-bromo, 3-iodo, and 3-nitro derivatives of 5,7-dimethyl-pyrazolo[l,5-a]pyrimidine derivatives were prepared by chlorination, bromination, iodination, and nitration of 3-unsubstituted 5,7-dimethyl-pyrazolo[l,5-a]pyrimidines. Reaction with bromine and potassium thiocyanate gave a 3-thiocyanato derivative, which was converted into the mercapto derivative upon saponification. Nitrosation gives the 3-nitroso derivative and acylation with trifluoroacetic anhydride affords the trifluoroacetyl derivative (74JMC645 77JMC386). [Pg.350]

Pyridazino[3,4-i)]quinoxalines and pyrazolo[3,4-i)]qumoxalme hydrochloride are synthesized by the 1,3-dipolar cycloaddition reaction of 6-chloro-2-(l-methylhydrazino)quinoxaline 4-ox-ide with dimethyl or diethyl acetylenedicarboxylate and a-chloroacrylonitrile, respectively. ... [Pg.255]

In contrast, the isomeric 5-aIkynylpyrazole-4-diazonium chlorides cyclized only after heating tol00-105°C for 2 h, giving good yields of the l,3-dimethyl-7-chloro-l//-pyrazolo[4,3-c]pyridazines 87 [98HEC519 99JCS(P1)3721] (Scheme 137). [Pg.68]

Further products prepared by the thionyl chloride method in solution are Dolastatin, a thiazole amino acid component (gln)Thz (70% yield) [1110], 4-phenyl-3-furoxanecarbonitrile (55% yield) [1111], ethyl 5-cyano-l-(l,l-dimethyl-ethyl)-lH-pyrazolo-4-carboxylate (61% yield) [1112], ethyl 2-anilino-4-chloro-5-cya-nothiophene-3-carboxylate (77% yield) [1113], and 4-cyanoisoxazole from its oxime tosylate (47% yield) [1114]. [Pg.380]


See other pages where 1.3- Dimethyl-7-chloro-1 //-pyrazolo is mentioned: [Pg.398]    [Pg.291]    [Pg.344]    [Pg.339]    [Pg.339]    [Pg.322]    [Pg.149]    [Pg.299]   
See also in sourсe #XX -- [ Pg.3 , Pg.4 ]

See also in sourсe #XX -- [ Pg.3 , Pg.4 ]




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5-chloro-3,7-dimethyl-5-

Pyrazolo -7

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