Dimethyl-amino-cinnamaldehyde

El-Kommos and Emara [47] determined primaquine and other secondary aromatic amines pharmaceuticals by a spectrophotometric method using 4-dimethyl amino cinnamaldehyde. The reaction of the reagent with primaquine and with the other amines was investigated. Powdered tablets were extracted with methanolic 0.1 M perchloric acid. The extract was mixed 1 1 with methanolic 0.2% of 4-dimethyl amino cinnamaldehyde and the mixture was diluted with methanol before measurement of the absorbance at 670 nm for primaquine phosphate. Beer s law was obeyed for 2-20 pg/mL of primaquine. The pink and green color formed with primaquine was stable for at least 24 h. Recoveries were good. Amodiaquine did not interfere with the determination of primaquine. 

Treutter, D. 1989. Chemical reaction of catechins and proanthocyanidins with 4-dimethyl amino cinnamaldehyde. J. Chromatogr. 467 185-93. 

The most relevant structural features of this new class of SPS co-crystals is that suitable guests are not only small molecules (both essentially apolar, like DCE[55] and highly polar, like 4-nitro-aniline [53]) but also long molecules like 4-(dimethyl-amino)-cinnamaldehyde, which exhibit a molecular volume too large to be enclosed as a guest into the 8 phase. 

Reaction of otfi-unsaturated acetals with silyl nucleophiles. This trityl salt is an efficient catalyst for reaction of the dimethyl acetal (2) of cinnamaldehyde with successive silyl nucleophiles to form y,5-unsaturated p-azido ketones. The azide group can be reduced to an amino group by the Staudinger reaction.1... 

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