Dimethoxymethane acetyl chloride reaction

Chloromethylatlon of Polysulfone A solution of chloromethyl methyl ether (6 mmole/ml) in methyl acetate was prepared by adding acetyl chloride (141.2 g, 1.96 mol) to a mixture of dimethoxymethane (180 ml, 2.02 mol) and anhydrous methanol (5.0 ml,0.12 mol). The solution was diluted with 300 ml of 1,1,2,2,-tetrachloroethane and SnCl (1.05 ml, 0.009 mol) was added. After the mixture was brought to reflux, a solution of polysulfone (40 g, 0.09 eq) in 500 ml tetrachloroethane was added slowly. Refluxing was maintained for 3 hours before the catalyst was deactivated by injecting 5 ml of water into the reaction mixture. The reaction volume was reduced to 400 ml before precipitating the chloromethylated polysulfone, in methanol. After reprecipitating from chloroform in methanol,... 

A new method has appeared for the synthesis of chloromethyl methyl ether, free of the carcinogenic bis(chloromethyl) ether. It consists of the reaction of acetyl chloride with catalytic methanol in the presence of dimethoxymethane (Scheme 28) the 1 1 mixture of chloromethyl methyl ether and methyl acetate... 

Acetyl-2-Dimethylsulfamylthioxanthene A suspension of 2-dimethylsulfamylthioxanthene (12.22 grams, 0.04 mol) in 60 ml of dimethoxymethane is cooled to 0°C and 17.2 ml of a 2.91 M solution of n-butyl lithium in heptane is added slowly in a nitrogen atmosphere while the temperature is maintained below 10°C. After an additional 10 minutes of stirring, the cooling bath is removed and a solution of 2.96 grams of methyl acetate in 20 ml of di-methoxyethane is added during % hour and then the mixture is stirred at 25°C for an additional 3 hours. The reaction mixture is then treated with 60 ml of ethyl acetate and with 60 ml of a 10% aqueous ammonium chloride solution. The layers are separated and the ethyl acetate layer is washed once with water (25 ml) and then the solvent is removed by distillation. 

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