6.7- Dimethoxy-2-methyl-1,2,3,4-tetrahydro

Analog erhalt man Brom- und Alkoxycarbonyl-substituierte Produkte wie z.B. 1-( 2-Brom-4-methoxycarbonyl-benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isochinolin (61%). Ein Beispiel aus der Steroid-Chemie ist die Herstellung von / 7fi-Dimelhylamino-3-hydroxy-17a-methyl-5-androsten aus einem Iminium-Salz2 ... 

Isopropyl-2-methoxy- VI/3, 304 Ethen l-Ethoxy-l-(2-methoxy-ethoxy)- VII/4, 350 Furan 2-(Dimethoxy-methyl)-tetrahydro- IV/lb, 128/E14a/1, 527 (aus 5,6-H2—4H-pyran + H3C-OH)... 

Bromomethyl-2,3-dimethoxy-7-methylquinoxaline (265) underwent a classical Sommelet reaction and incidental hydrolysis of the methoxy groups to give 7-methyl-2,3-dioxo-l,2,3,4-tetrahydro-6-quinoxalinecarbaldehyde (266) (hexamethylenetetramine, CHCI3, 20°C reflux, 30 min solid from evapora-... 

Nitropyrido[l,2-A]quinolin-6-ium-l 1-olate (6%) was isolated from a reaction mixture obtained by photoirradiation of crystalline photochromic 2-(2, 4 -dinitrobenzyl)pyridine for 10 days <2004JP0865>. Reaction of l-(3-chloropropyl)-6,7-dimethoxy-3-methylbenzo[c]pyrylium perchlorate with hydrazines and hydroxylamine in refluxing MeOH afforded 9,10-dimethoxy-6-methyl-, -4,6-dimethyl-l,2,3,4-tetrahydropyridazino[6,l-tf]isoquinoli-nium, and 9,10-dimethoxy-6-methyl-l,2,3,4-tetrahydro[l,2]oxazino[3,2- ]isoquinolinium, perchlorates, respectively <2004CHE1131>. 

Cyclization occurred at the N-3 atom when 4-(3-bromopropylaruino)-l, 6,7,1 1 b-tctrahydro-2//-pyrimido[6,l -zz -isoquinoline was treated with NaH to give a tetracyclic derivative <2003M1271>. 9,10-Dimethoxy-2-(arylimino)-2,3,6,7-tetrahydro-4//-pyrimido[6,l- ]isoquinolin-4-ones were N-3-alkylated with iV-(ra-bromoalkyl)phthalimides in the presence of K2C03 and a catalytic amount of I2 in boiling 2-butanone in 13-67% yields <2000W020/058308>. Treatment of the 2-[(4-methoxyphenyl)methyl] derivative of 2,3,6,7-tctrahydro-l //,5//-pyrido[3,2,l-/ylqninazolinc-... 

Atracurium Atracurium is 2,2 -[l,5-pentanediylZtM[oxy(3-oxo-3,l-propanediyl)]] bis [l-[(3,4-dimethoxyphenyl)methyl]-l,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquino-Unium] dibenzene sulfonate (15.1.12). This compound is synthesized from (tw-acrylic ester of 1,5-pentandiol (15.1.10), which is synthesized from acrylic acid chloride and 1, 5-pentandiol. Two molecules of a secondary amine, tetrahydropapaverine, are joined to the product in a Michael reaction, forming compound (15.1.11). Then both nitrogen atoms are methylated by methylbenzenesulfonate, giving atracurium (15.1.12) [17-19]. 

R,5 S)-2-[(2-bromomethylphenyl)methyl -2,5-dihydro-5-mpropyi-3,6-dimethoxy-2-meth ipyrazme >97% de 6 (3, 11 aR)-3,4,6, t t-tetrahydro-3-isoprop I-l-methoxy-U a-methyl-4-oxopyrctzino[l, 2-b isoquinoline yield 75% 97% de... 

HjC jO x (SI 1. N [BH4]/CH3OH -78° [2. H2/Pd-C/C2Hs0H/HCl/H2O] 1. 6,7-Dimethoxy-1-methyl-2-( 1-phenyl-ethyl )-l, 2,3,4-tetra-hydro-tsochinolin 2. [- (S)-6,7-Dimeth-oxy-1-methyl-1,2,3,4-tetrahydro-isochino-lint(S)-SalsolidmJ] 77 r 3... 

Die Stevens-Umlagerung von 2-Benzyl-7,8-dimethoxy-2-methyl-l,2,3,4-tetrahydro-isochinolinium-bromid mittels Phenyl-lithium ergibt l-Benzyl-7,8-dimethoxy-2-methyl-l, 2,3,4-tetrahydro-isochinolinz ... 

Isoquinohne, 1,2,3,4-tetrahydro-2-methyl-l-(2-phenylethyl)-, 56, 7 Isoquinohnes, alkylation of, 56, 19 Isoquinohmum, 2-ethyl-3,4-dihydro-6,7-dimethoxy-l-phenyl-, iodide, 56, 7 ISOXAZOLE, 3-(4-chlorophenyl)-5-(4-methoxyphenyl)-, 55, 39 Isoxazole, 5-(4-chlorophenyl)-3-(4-meth-oxyphenyl)-, 55, 42... 

CjHjS, Thiophene, tetrahydro-gold complexes, 26 85-87 C4H,NO, 2-Propenamide, 2-methyl-nickel complex, 26 205 C4H1()02, Ethane, 1,2-dimethoxy-solvates of chromium, molybdenum, and tungsten carbonyl cyclopentadienyl complexes, 6 343 tungsten complex, 26 50 ytterbium complex, 26 22 C4H i02.NaC5H5, Ethane, 1,2-dimethoxy-compd. with cyclopentadienylsodium, 26 341... 

Heating 6-(4-chloro-3-hydroxybutyl)-2,4-dimethoxy-5-methylpyrimidine in MeOH saturated with gaseous NH3 at 60 °C overnight gave 7-hydroxy-3-methoxy-4-methyl-5,6,7,8-tetrahydro-lH-pyrido[l,2-c]pyrimi-din-l-one in 72% yield (05MI3). 

Chemical Name (+/-)-6,7,8,9-Tetrahydro-2,12-dimethoxy-7-methyl-6-(2-phenylethyl)-5H-dibenz[d,f]azonin-l-ol hydrochloride... 

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