Dilantin Kapseals

Wood, R. W., Clemente, W., Lambert, McShane, J. (190ffi)gle Dose Pharmacokinetic Comparison of Oral Phenytoin Administered as a Novel Nanocrystal Dispei dE( lantin-125 Suspension or Dilantin Kapseals, 24th Annual Meeting ACCP... 

Dilantin Kapseals are extended with a 6 to 8 h absorption phase allowing once-a-day dosing. 

Phenytoin is used orally for the prevention of generalized (grand mal) and partial complex seizures. Intravenous phenytoin is used to treat status epilepticus and occasionally as an antiarrhythmic agent. Oral formulations include suspensions, capsules, and tablet preparations. The brand Dilantin Kapseals exhibits delayed absorption characteristics not usually shared by generic products. 

Dilantin Kapseals (Phenytoin sodium). Pfizer Inc. US Prescribing information, September 2006. 

However, in contrast, a study in 10 healthy subjects found that when Ensure or Vivonex TEN was given every 4 hours for 24 hours, the absorption of a single 400-mg dose of phenytoin was unaffected. Similarly, a single-dose study in healthy subjects found that the bioavailability of phenytoin sodium 400 mg in a capsule formulation (Dilantin Kapseals) was not affected by concurrent enteral feeds (Ensure) ... 

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