Dihydrosphingosine phosphate

Sphingosine-1-phosphate receptors EDG-1 and EDG-3 bind SIP generated from phosphorylation of sphingosine by sphingosine kinase. The binding of SIP and sphinganine 1-phosphate (dihydrosphingosine 1-phosphate) to EDG-1 promotes chemotaxis via a Gai-mediated mechanism. [Pg.164]

FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells. /. Biol Chem., 284 (9),... [Pg.61]

DihydrosphmBosine -f ATP dihydrosphingosine phosphate Dihydrosphingosine phosphate palniitaldchyde ethanolamine phosphate... [Pg.608]

The principal sphingosylphosphatide component of yeast, fungi, and slime molds is inositol phosphorylceramide (Ins-PCer, compound 3, Fig. 3), which has a phytoceramide or dihydrosphingosine backbone and an inositol phosphate head group. InsPCer is formed in a reaction catalyzed by Ins-... [Pg.1762]

Diglycosyldiphytanylglycerol diether, 158 Dihydroperoxides, 455 Dihydrosphingosine, 281,439 Dihydroxystearic acids, 57 Dihydrosterculic acid, 53 Dihydroxy acetone phosphate, 504 Dihydroxyhexadecanoic acid, 44 Diimine, 452 Dilatation, 253,254,374 Dilaurin, 366,367... [Pg.563]

The pathway by which sphingosine is formed was elucidated first by the German biochemist Stoffel in Koln. He demonstrated the pathway by isolating intermediates and thus disproving a previously accepted alternative scheme. The first intermediate is 3-ketodihydrosphingosine, which is formed by the condensation of palmitoyl-CoA with serine in the presence of pyridoxal phosphate. NADPH is then used for the reduction of the intermediate to dihydrosphingosine ... [Pg.318]

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