Dihomogammalinolenic acid

When GLA-rich oils are taken orally, GLA is rapidly absorbed. It first appears in serum phospholipids, and with continuous administration, it is distributed in other phospholipid fractions. Part of absorbed GLA is oxidized, and the rest is taken up by various tissues/ceUs and is rapidly elongated to dihomogammalinolenic acid (DGLA) (Figure 1). The oxidation rate of GLA was found to be 28% of that for... 

El-Boustani S, Descomps B, Monnier L, et al. In vivo conversion of dihomogammalinolenic acid into arachidonic acid in man. Prog Lipid Res 1986 25 67-71. 

Some acids are conveniently made by a combination of isolation and synthesis. For example, dihomogammalinolenic acid (20 3 n—6) is best obtained from gammalinolenic acid (18 3 n—6), itself isolated from evening primrose oil, by chain extension by two carbon atoms (malonation). 

Dihomogammalinolenic acid Minor component of animal phospholipids. Metab. of Linoleic acid. Precursor of PGi series of prostaglandins. 

Dihexyl ketone, see T-00156 Dihomogammalinolenic acid, in 1-00037 >Dihydroambrettolide, in H-00276 Dihydrobrassicasterol, in M-OOOl 1... 

Manku, M. S., Oka, M., and Horrobin, D. F., 1979, Differential regulation of the formation of prostaglandins and related substances from arachidonic acid and from dihomogammalinolenic acid. II. Effects of vitamin C, Prostaglandins Med. 3 129-137. 

Guichardant, M, Traitler, H, Spielmann, D, Sprecher, H and Finot, PA (1993) Stearidonic acid, an inhibitor of 5-lipoxygenase pathway. A comparison with timnodonic and dihomogammalinolenic acid. Lipids, 28, 321—324. 

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