Digoxin specific antibody

Butler, V.P. Schmidt, D.H. Smith, T.W. Haber, E. Raynor, B.D. and Demartini, P. Effects of sheep digoxin-specific antibodies... 

V. P. Butler, Jr., D. H. Schmidt, T. W. Smith, E. Haber, B. D. Raynor, andP. Demartini, Effects of sheep digoxin-specific antibodies and their Fab fragments on digoxin pharmacokinetics in dogs, J. Clin. Invest. 59, 345-359 (1977). 

Zdunek M, Mitra A, Mokrzyeki MH. Plasma exchange for 209. the removal of digoxin-specific antibody fragments in renal failure timing is important for maximizing clearance. Am J Kidney Dis 2000 36(l) 177-83. 

Rabetoy GM, Price CA, Findlay JW, SaUstad JM. Treatment of digoxin intoxication in a renal failure patient with digoxin-specific antibody fragments and plasmapheresis. Am J Nephrol 1990 10(6) 518-21. 

Smolarz A, Roesch E, Lenz E, et al. (1985) Digoxin specific antibody (Eab) fragments in 34 cases of severe digitalis intoxication. Journal of Toxicology. Clinical Toxicology 23 327-340. 

Symptomatic and supportive treatment, in addition to digoxin-specific antibody fragments, can be effective for oleander toxicity. 

VP Butler, JP Chen. Digoxin specific antibodies. Proc Natl Acad Sci (USA) 57 71, 1977. 

Withdrawal of the drug usually results in recovery, but severe digoxin toxicity can be treated in an emergency by intravenous injection of digoxin specific antibody fragment, which neutralizes toxic effects. 

II. Indications. Digoxin-specific antibodies are used for life-threatening arrhythmias or hyperkalemia (>5 mEq/L) caused by cardiac glycoside intoxication (see p 155). 

There is little literature on the clinical effects of a digoxin-specific antibody known as... 

Smith, Th.W., Haber, E., Yetman, L., and Butler, V.P. (1976) Reversal of advanced digoxin intoxication with F fragments of digoxin-specific antibodies. New Engl. J. Med. 294 797-800. 

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